Autism and the Use of MRI - Free Essay Example

Abstract In this paper, the relationship between autism spectrum disorder (ASD) and the use of magnetic resonance imaging will be discussed. Autism is a very common neurodevelopment disorder with many different symptoms. Diagnosing and treating autism can be challenging because of how different every case of ASD truly is. Early detection is important for getting ahead on treating the symptoms that go along with ASD to create more positive outcome for the patients. Using MRI can open the doors for doctors and researchers to learn even more about this disorder and how to treat it. The studies discussed in this paper will explain how the use of structural MRI can allow physician to see how an autistic patient’s brain size and appearance differs from typically developing individuals, and the use of functional MRI can be used to compare the brain’s activity. Sleep fMRI is also discussed in how it can help with early detection in children. Overall, the discussion is about how MRI can better the understanding, detection, and treatment of ASD. Autism and the Use of MRI Autism spectrum disorder (ASD) is a neurodevelopment condition that has a wide variety of symptoms that can effect a patient’s social skills, speech or other ways of communication, and also can include different repetitive behaviors. One third of children with autism are nonverbal, and there are also many children that have gastrointestinal disorders, anxiety, and attention deficit hyperactive disorder (ADHD) along with many other symptoms. The conditions of ASD are very diverse because every case can be so unique because of different genetic and environmental blends can effect an ASD patient’s conditions. Around 1 in 68 children are effected by autism, and boys are much more likely to have the disorder. Diagnosing autism can become a process; usually, if a parent or physician is concerned of ASD being a possibility, they will do a general screening which is normally suggested to the parents of infants anyway. After the screening, if there is a strong possibility of the patient having autism, the doctor will do a complete evaluation to confirm the diagnosis of the patient (Autism Speaks, n.d.). According to Shen et al (2013), early detection is critical because the earlier ASD is diagnosed positive results are more likely to happen when treating impairments. Most of the time diagnosing and understanding autism is only done by observation or screening, but with radiology, doctors are now seeing the signs of autism with magnetic resonance imaging (MRI) which could lead to an earlier detection. There are multiple types of MRI that can help with these studies. Structural MRI is used to understand the anatomy of the brain. The data received from structural MRI can explain shape, size, and white and gray matter within the brain. Structure can be very important when understanding function of the brain, and this is why structural MRI is so useful. The next form of MRI is used for mostly neural activity rather than anatomy. Functional MRI can use tasks or something visual to stimulate the brain, and then doctors can compare the changes of neural function and compare the results with other patients. Using these two functions of MRI can help doctors or researchers understand normal or unusual brain function. Also, fMRI and structural MRI aid in the research or treatment involving neurological disorders (Center for Functional MRI, n.d.). Throughout this first study, the use of structural MRI for studying autism is discussed; also, the comparison of the brain between patients with ASD and typical developing individuals. With the help of MRI, doctors can study the brain without anything invasive and allows researchers or doctors to view the structural changes of patients with ASD. These studies look for the differences between patients with autism and how their brain growth persists the older they get using structural MRI. With structural MRI, the brain volume in children with autism can be observed and compared. Multiple scans were performed on young children throughout the ages of a year and a half to five years who all were confirmed to have autism at around the age of four years old, and the researchers also performed scans on children without autism. When the scans were studied, it was found that most children with ASD had a cerebrum and many other divisions of the brain that were enlarged by th e time the patient was two and a half. These studies have found that young children with autism have atypical enlargement of brain volume compared to normal developing children (Chen, Jiao, Herskovits 2011). According to (Chen et al., 2011), the enlargement seems to relate to an increase in â€Å"gray-matter (GM) and white-matter (WM) volumes.† Although enlargement is found within children, it is vague if whether or not the enlargement continues as the child gets older. Although the enlargement is seen within children, there have also been reports of autistic adults with substantially smaller parts of the brain within the corpus callosum. Throughout these MRIs, many differences and abnormalities were seen throughout the scans. Consistent abnormalities were seen throughout the patients’ white matter, frontal and temporal lobes, as well as other parts of the brain (Chen et al., 2011). Pointing out the abnormalities becomes difficult because the symptoms of ASD cannot be found as a result of one specific part of the brain; the multiple symptoms of autism could be explained by certain neural systems and how they perform together (Dichter, 2012). These studies are an example of how magnetic resonance imaging can assist doctors in identifying they physical differences between patients with ASD and typicall y developing individuals (Chen et al., 2011). In the next study reviewed, they researched the relationship between extra-axial fluid and children who develop autism spectrum disorder. This study differs because the children involved in the study had not yet been diagnosed with autism. The study began with 64 infants, 41 of who were high risk because they had sibling with ASD. The other 23 participants had no relatives with the disorder and were considered low risk. Throughout the case, the number of participants decreased to 55 children (33 high risk and 22 low risk). The participants were scanned three times during sleep using a 3 Tesla Siemens TIM Trio MRI system from the ages of six months to 24 months. After the series of scans were complete, there seemed to be a trend with the high risk children. Some of the high risk children who participated in the study had similarities within the subarachnoid space. According to Shen et al. (2013), the children had â€Å"the presence of ‘prominent extra-axial fluid.’ Extra-axial fluid is characterized by excessive cerebrospinal fluid (CSF).† After the scans were completed and the children were old enough to be diagnosed, ten of the high risk children were classified to have ASD at 24 months old, and eight of them were officially diagnosed at 36 months old. Eight of the other children who were high risk had developmental delays, and only three children from the low risk group had developmental delays, but none of them were diagnosed with ASD. There are many features that extra axial fluid and autism spectrum disorder share. Shen et al. (2013) explained that these traits include â€Å"enlarged head circumference early in life, higher rate in boys than girls, and a co-occurrence with seizures.† Although there has been no previous relationship between ASD and extra axial fluid, increased cerebrospinal fluid has been found in patients with autism. After this study and research was conducted, the results concluded that if the presence of the significant amount extra axial fluid has not gone away by the time the child is two years old that it could be a possible symptom of autism in children. This study would not have been possible without the use of MRI and also shows how imaging could help with early detection of children with autism. (Shen et al., 2013). This study showed how certain things that were seen in children with ASD could potentially be seen before the normal time of diagnosis. According to Dichter (2012), MRI (fMRI) â€Å"has proven to be a useful tool to investigate aberrant neurobiological function in ASDs because of its excellent contrast properties, spatial resolution, and temporal resolution.† Although fMRI can be very useful, it can become difficult when performing the scans on children. Children are not able to undergo functional MRI because the scans cannot be completed if they are awake or alert because the procedure must be done with the patient completely still. FMRI has become possible to perform the procedure with children by doing the scan during nature sleep which is known as sleep fMRI. This allowed doctors to understand more about an autistic child’s brain function in which they have been unable to do before. FMRI is allowing doctors to see some of the earliest signs of autism which is vital for the future of a child with ASD (Pierce 2011). According to Pierce (2011), sleep fMRI can allow doctors to make a diagnosis even earlier than they thought possible and will allow treatment to occur much sooner. With autism spectrum disorder being so common and the diversity of behaviors with autistic children, the use of MRI is opening the doors for doctors to detect the early signs and to understand even more about the disorder. Structural MRI and functional MRI can both play very important roles for studying ASD. Structural MRI allows researchers to observe the differences between brain volume in typical developing children and in children with autism, and functional MRI allows doctors to review brain activity and function. Sleep fMRI is also becoming the way for doctors to make even earlier detection because it allows them to perform scans on patients at a much younger age. With the research being done and early detection becoming even more possible, advances in imaging are creating a clearer picture of what parts of the brain are different for children and adults with ASD and how this effects their brain activity. With imaging, individuals with ASD can have the possibi lity of more positive treatment because of even earlier detection, and doctors can have a better ability of understanding autism and the parts of the brain it effects. References Autism Speaks. (n.d.). What is autism? Retrieved from https://www.autismspeaks.org/what- autism Chen, R., Jiao, Y., Herskovits, E.H. (2011, May). Structural MRI in autism spectrum disorder. Pediatric Research, 69(5 pt 2), 63R-68R. doi: 10.1203/PDR.0b013e318212c2b3 Center for Functional MRI. (n.d.). What is fMRI? Retrieved from https://fmri.ucsd.edu/Research/whatisfmri.html Dichter, G.S. (2012, September 14). Functional magnetic resonance imaging of autism spectrum disorders. Dialogues Clinical Neuroscience. 14(3), 319-351. Pierce, K. (2011, March 22). Early functional brain development in autism and the promise of sleep fMRI. Brain research, 1380, 162-174. doi: 10.1016/j.brainres.2010.09.028. Shen, M.D., Nordnal, C.W., Young, G.S., Wooton-Gorges, S.L., Lee, A., Liston, S.E., Harrington, K.R., Ozonoff, S., Amaral, D.G. (2013). Early brain enlargement and elevated ex tra-axial fluid in infants who develop autism spectrum disorder. Brain: A journal of neurology, 136, 2825-2835. doi: 10.1093/brain/awt166

Margaret Atwood The Landlady Poem - 808 Words

Margaret Atwood’s poem â€Å"The Landlady† is an illustration of isolation on the mind when facing a mental illness. A mental illness, such as depression or anxiety, controls the person from within taking over their lives, just like the Landlady is said to do. The poem represents depression through the characterization of the landlady as being loud, controlling and isolated from freedom. Depression takes over one’s life like the landlady has over her tenants. The poem begins with â€Å"this is the lair of the landlady,† which indicates her home to be it to be an intimidating and freighting, setting in place the melodramatic and haunting tone of the story. A lair is a resting or hiding place for an animal, but it is used also as a place of residence†¦show more content†¦Ã¢â‚¬Å"She presides over my meagre eating,† like every action is through the landlady’s knowledge and permission, as â€Å"she is everywhere.† She â€Å"generates the light for eyestrain,† which however does prove she provides economically and financially with necessities, she still causes harm from every action she performs, much like depression. â€Å"She slams my days like doors,† asserting the power she has over her tenant’s life. Even in sleep, the occupant is unable to escape from her clutches as she appears in dreams. Stanza 6, indicates the â€Å"vast face† over which appears in his, as an extensive lan d, as the landlady is everywhere so there is no escape. Likewise, Atwood’s play of words of â€Å"from her I rent my time† illustrates the life of the renter, no longer belongs to him/her, if its being controlled by someone or something else. Similarly, the landlady restricts her tenant’s freedom through her authority. In stanza 7, she is described as â€Å"a knot swollen in space† where there is no way to untie her no matter how hard one tries. The renter is unable to defeat her force, just like depression may seem invincible, so there needs to be a way around it instead. â€Å"She stands there, a raucous fact blocking my way† indicates that she causes obstruction to the freedom the occupant desires. â€Å"Raucous† specifically refers to a harsh or loud noise further clarifying her insolent personality. Likewise, there is no escape from depression as it is within a person’s mind. One

Accountability Is The Foundation For Humanitarian Aid

Accountability is the foundation for humanitarian aid because it dictates the level of effectiveness of the response. Also, it allows humanitarian agencies to manage risk in disastrous situations and affected populations. As defined by HAP, â€Å"Accountability is the means through which power is used responsibly. It is a process of taking into account the views of, and being held accountable by different stakeholders, and primarily the people affected by authority or power† (HAP, 2010). HAP clarifies that when referring to power and accountability, it does not mean that the agencies have power over the community. However, the agencies have the responsibility to control the way power is used within these crisis-affected populations. Regardless,†¦show more content†¦The example of Typhoon Haiyan response upholds how a more organized and relevant approach to approving AAP will initiate more support of networks. Aside from the Haiyan response, there are have been other a ttempts at improving accountability within humanitarian agencies. Another example is the Pakistan Accountability Learning Working Group (ALWG) is a way to link accountability both globally and locally. Lastly, Sierra Leone is an example of how humanitarian agencies attempt to collect data about the affected areas in hopes of a more comprehensive approach. In order to develop better accountability methods, it must have a consolidated approach, which means that the agencies must understand the area they are serving. Humanitarian agencies should have the intentions of listening and responding to the needs of these affected areas, listening is not adequate. 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The yearbook of International Organizations identifies over 6,500 non-governmental organizations that have an international dimension either in terms of membershipRead MoreWhat Can Be Done For The U.n Peacekeeping Force?1895 Words   |  8 Pagesdegradation of foreign lands. The first key issue with the UN administration is the staff itself. Recent studies find that the UN administration lacks the basic knowledge and qualifications to implement a successful mission. The United States Government Accountability Office finds in April of 2006 that the â€Å"Procurement Service staff did not appear to have a clear understanding of procurement policies and procedures, resulting in inconsistent application of procurement policies.† The report goes on to reveal

Pitfalls of the American Dream in of Mice and Men free essay sample

I feel that I am a citizen of the American Dream and that the revolutionary struggle against the American nightmare. † This quote by Eldridge Cleaver states that one has the right to achieve the American Dream however, there are factors that work against one trying to achieve the American Dream. We will write a custom essay sample on Pitfalls of the American Dream in of Mice and Men or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page In John Steinbeck’s â€Å"Of Mice And Men† , the pitfalls of the American Dreams are more effectively demonstrated in comparison to the movies directed by Gary Sinise. Towards the beginning of the movie one can easily point out differences that were not in the novel. For example, in the book, Lennie and George were aware of Curley’s arriage. â€Å"He got married a couple of weeks ago. Wife lives over in the bosss house (13). However, in the movie the men are not aware of Curley’s wife before she come into the room. This helps to give readers a hint on how this women will play a role in their failure at achieving the American Dream. In both the movie and the book, a women running for her life in a memorable red dress is presented, â€Å"He jus wanted to touch that red dress, like he wants to pet them pups all the time(3. 28-30) It is later revealed that Lennie touched her and for that he was on the run. After the introduction of Curley’s wife, one can infer that something similar will happen with her and that this women will also be a pitfall in achieving the American Dream. Thas good, he said. You drink some, George. You take a good big drink. He smiled happily. (1. 7) In this quotes from the book, the readers are lead to conclude that Lennie has mental disabilities as he can be compared to a child. In both the movie and the book, Lennie’s disabilities are displayed which can later on be a pitfall in achieving the American Dream. Run us out, hell, said George disgustedly. We run. They was ookin for us, but they didnt catch us (1. 50-55) Both the movie and the book reveal the situation that occurred in the weeds, George and Lennie’s previous Jobs. Based on events from the past, readers can foreshadow that history will repeat it self which can add to the failure in achieving the American Dream. It is clear that many do not travel together. Aint many guys travel around together, he mused. I dont know why. Maybe everbody in the whole damn world is scared of each other' (35). In both the book and the movie, Slim states that he doesn’t really see many traveling together. In the book however, a better understanding of why men don’t travel together is created. Overall this quotes from the book can aid readers to predict that George and Lennie will not stay together after all and that their friendship will be put to the test. With this being said, their dream will be at risk. The crash of the shot rolled up the hills and rolled down again (106) Towards the end of both the movie and the book, George shoots Lennie. As it was previously predicted, Lennie’s past has caught up to him as he again has violated a women. In this case he has killed Curley’s wife. Due to her death, Curley has vowed to make Lennie suffer. George felt the need to take matters into his own hands and kill Lennie. This event in both the movie and the book highlight the major pitfall of the American Dream. Now that Lennie is dead, the American Dream will not be achieved. However, the book demonstrated this pitfall by creating a better vivid image of what occurred. After analyzing both the movie and the book, one can conclude that John Steinbeck’s â€Å"Of Mice And Men† demonstrates the pitfalls of the American dream better than the move â€Å"Of Mice And Men† directed by Gary Sinise.

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The Writing College Term Papers Diaries

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How to Write a Social Argumentative Essay Topic For College

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